Discover the critical link between blood markers and survival outcomes in diffuse large B-cell lymphoma through our latest systematic review and meta-analysis on red blood cell distribution width and D-Dimer.
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Prognostic value of red blood cell distribution width and D-Dimer in diffuse large B-cell lymphoma: Systematic review and meta-analysis.
Rahchamani et al., Cancer Rep (Hoboken) 2023
DOI: 10.1002/cnr2.1936
What’s New: This meta-analysis investigates the prognostic significance of red blood cell distribution width (RDW) and D-Dimer levels in patients with diffuse large B-cell lymphoma (DLBCL).
Importance: The study provides evidence that elevated RDW and D-Dimer levels are associated with poorer overall survival (OS) and progression-free survival (PFS) in DLBCL patients, which could help in risk stratification and management of the disease.
Contribution to Literature: The analysis consolidates data from 13 studies, showing that high RDW is linked to poor OS (Hazard Ratio [HR] = 2.01, 95% Confidence Interval [CI]: 1.62-2.48, p < .01, no heterogeneity with I2 = 0%) and PFS (HR = 1.52, 95% CI: 1.24-1.85, p < .01, low heterogeneity with I2 = 16%). Increased D-Dimer is also significantly related to poor OS (HR = 2.30, 95% CI: 1.03-5.14, p < .05, high heterogeneity with I2 = 95%). The study highlights the potential of RDW and D-Dimer as biomarkers for DLBCL prognosis, with no significant heterogeneity for RDW across studies (OS p-value H = 0.65, PFS p-value H = 0.31).