Let me tell you, folks, we’ve got something incredible here. It’s all about making things better, faster, and stronger. We’re talking about tissue regeneration, a big deal, right? And what’s at the heart of it? The inflammatory response. But, hold on, we’ve found a game-changer: spermidine. Yes, spermidine. It’s not just any substance; it’s inspired a breakthrough – an injectable hydrogel that’s like nothing else.

This isn’t your ordinary hydrogel. No, it’s a double network hydrogel, functionalized with spermidine, called DN-SPD. Imagine two networks, one dynamic, one not, working together like a well-oiled machine. Before we even get to the photo-crosslinking, this hydrogel is so easy to use, you can inject it, print it, and then solidify it right in the body. And let me tell you, its mechanical properties and tissue adhesion? Top-notch.

But here’s where it gets really interesting. We did a comparison, an “operando” comparison, if you will, between our spermidine-loaded hydrogel and another with a sham molecule, DETA. They might look similar, but when it comes to biology, it’s a whole different ball game. Our DN-SPD hydrogel? It’s not just reducing inflammation; it’s turning those macrophages into the good guys, the M2 phenotype, promoting healing like you wouldn’t believe.

And the results? They speak for themselves. Inflammation down, healing up, for both acute and diabetic wounds. It’s a simple solution, but let me tell you, it’s elegant. Spermidine, folks, it’s not just helping; it’s revolutionizing how we treat wounds. We’re talking about a faster, more natural healing process. This is the future, and it’s here today. Believe me.