Dive into the groundbreaking study on how metabolomics in human SGBS cells offers a novel approach to understanding adipogenic effects, focusing on the impact of DINCH and MINCH on central carbon metabolism.
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Metabolomics in human SGBS cells as new approach method for studying adipogenic effects: Analysis of the effects of DINCH and MINCH on central carbon metabolism.
Goerdeler et al., Environ Res 2024
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https://doi.org/10.1016/j.envres.2024.118847
This study investigates the impact of the plasticizer diisononyl-cyclohexane-1,2-dicarboxylate (DINCH) and its metabolite monoisononyl-cyclohexane-1,2-dicarboxylic acid ester (MINCH) on human adipocytes, amid concerns that metabolism-disrupting chemicals (MDCs) like DEHP may contribute to obesity. Utilizing metabolomics on human SGSB cells exposed to DINCH or MINCH, the research found that MINCH, at high concentrations (10 μM), can induce lipid accumulation similarly to the known adipogenic agent rosiglitazone. This effect is partly mediated through a PPARG-independent mechanism and involves upregulation of the pyruvate cycle, crucial for lipogenesis. However, the effects were not observed at concentrations relevant to current human exposure levels, suggesting no significant adipogenic potential of DINCH and MINCH under physiological conditions. This study introduces a novel method for assessing the adipogenic effects of environmental chemicals, supporting its use as a New Approach Method (NAM) and contributing to the understanding of MDCs’ impact on obesity at realistic exposure levels.