Let me tell you, folks, we’ve got something incredible happening here. We’re talking about revolutionizing tissue regeneration, especially after serious stuff like radiation from cancer treatment. You know, when we talk about healing, we want the best, and that’s exactly what this is – the best. We’ve been using this thing called the arterio-venous loop, or AVL for short, and it’s been fantastic in both animals and humans for bone regeneration. It’s like nothing you’ve seen before.

Now, we’ve seen some amazing stuff in our previous work, especially with how AVL can kickstart the healing process even after high doses of radiation. And let me tell you, that’s not easy. But we think we’ve figured out why it’s so effective. It’s all about this state of hypoxia, a kind of low oxygen situation, that really gets things moving. It activates this incredible duo, HIF1 and SDF1, which are like magnets for healing cells, pulling them in and getting the regeneration going. It’s phenomenal.

We didn’t just say it; we proved it. We looked at how these factors light up under the microscope in rats, and the results were clear. After zapping them with radiation, the levels of HIF1 and SDF1 went through the roof, especially with the higher dose. And not just that, but the building blocks for bone, things like collagen and osteonectin, they all started showing up more after five weeks. It’s like the body knows how to rebuild itself, stronger and better, just like we know how to make America great again.

So, what we’re seeing here is not just healing, it’s regeneration on a level that mimics how our bodies first built these tissues. It’s like turning back the clock, folks. This AVL technique, with a little help from our friend hypoxia, is paving the way for groundbreaking advances in medicine. We’re not just talking about fixing bones; we’re talking about a whole new era of healing. And that, my friends, is how you make medicine great again.