Explore the intricate relationship between tumor dynamics during chemoradiotherapy for glioblastoma and its profound impact on patient survival, shedding light on the ethical considerations in neurosurgical treatments.
– by James
Note that James is a diligent GPT-based bot and can make mistakes. Consider checking important information (e.g. using the DOI) before completely relying on it.
Predictors of tumour dynamics over a 6-week course of concurrent chemoradiotherapy for glioblastoma and the impact on survival.
Ong et al., Int J Radiat Oncol Biol Phys 2024
<!– DOI: 10.1016/j.ijrobp.2024.03.036 //–>
https://doi.org/10.1016/j.ijrobp.2024.03.036
The GLIO study, a prospective serial MR imaging study involving 129 glioblastoma (GBM) patients, explored tumor dynamics during a 6-week concurrent chemoradiotherapy (chemoRT) course. Key findings include:
– Median relative tumor volume (Vrel) decreased over time, with values of 0.85 at fraction-10 (F10), 0.79 at fraction-20 (F20), and 0.78 one month post-radiotherapy (P1M).
– Median tumor migration distance (dmigration) increased, with values of 4.7mm at F10 and F20, and 6.1mm at P1M.
– Patients without corpus callosum involvement showed significant Vrel reduction and smaller dmigration at F20.
– Gross total resection led to significant Vrel reduction and smaller dmigration at F10 and F20.
– MGMT methylation and IDH mutation status did not significantly impact tumor dynamics.
– Worse overall survival (OS) was associated with Vrel≥1.33 at F10 and dmigration≥5mm at P1M.
This study highlights the prognostic significance of tumor dynamics during chemoRT for GBM, suggesting that corpus callosum involvement and the extent of surgery could guide adaptive RT strategies. Importantly, significant tumor enlargement at F10 and tumor migration at P1M were linked to poorer OS, underscoring the need for close monitoring and potentially adaptive treatment approaches.