The study introduces the lateral retrocanthal transorbital endoscopic approach (LRCTEA), a novel surgical method aimed at accessing the middle fossa of the skull while preserving the lateral canthal tendon to minimize postoperative complications like eyelid malposition. Through a detailed examination on 7 cadaveric heads, which were pre-scanned with high-resolution CT, the authors successfully demonstrated LRCTEA’s effectiveness in reaching critical areas such as the cavernous sinus, Meckel’s cave, and medial temporal lobe. Utilizing electromagnetic neuronavigation, they confirmed the approach’s precise trajectories and endpoints. This research not only outlines a stepwise technique for LRCTEA but also emphasizes its potential to enhance neurosurgical options for treating complex skull base pathologies. Despite its benefits, the authors caution about possible risks including transient diplopia, orbital hematoma, or optic apparatus damage, highlighting the importance of surgeon awareness to these complications. This advancement represents a significant contribution to the field, offering a safer and more effective method for challenging neurosurgical interventions.