Optimizing Folic Acid Dosage for Pregnant Women with Epilepsy on Antiseizure Medication

Explore the latest insights on the prescribing patterns for higher dose folic acid in pregnant women with epilepsy on antiseizure medication, and understand its significance for maternal and fetal health.
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Prescribing patterns for higher dose folic acid in pregnant women with epilepsy treated with antiseizure medication.

Vegrim et al., Epilepsia 2024
<!– DOI: 10.1111/epi.17969 //–>
https://doi.org/10.1111/epi.17969

Ho-ho-ho! Gather around, my dear friends, for I have a tale from the snowy lands of Denmark, Norway, and Sweden, not about elves or reindeer, but about a study as intriguing as the mystery of how I fit all those presents into my sleigh. This story unfolds in the realm of health, where researchers embarked on a festive journey to understand the use of a magical ingredient called folic acid, particularly doses higher than 1mg daily, among women with epilepsy treated with antiseizure medication (ASM) during the most magical time of their lives – pregnancy.

In this observational sleigh ride, the researchers delved into the vast toy workshops of national medical birth, patient, and prescription registers across the three lands from 2006 to 2017. They were on a quest to find pregnancies in women with epilepsy who were under the spell of ASM. Out of a grand total of 2,748,882 pregnancies, they discovered 8,695 (.3%) special ones that fit their criteria. Now, here’s where the plot thickens like the icing on my Christmas cookies: 4,719 (54.3%) of these pregnancies were sprinkled with higher doses of folic acid.

The most generous sprinkle was found in Sweden (74.3%), with Norway (41.4%) and Denmark (34.3%) being a bit more conservative with their folic acid dusting. However, like finding out that not all chimneys are easy to navigate, the researchers noticed a trend as disappointing as a lump of coal: the use of higher dose folic acid was on the decline in Denmark and Norway from 2012 to 2017. And here’s a twist – 42% of these women didn’t start their folic acid supplementation until after the stork had made its delivery plans.

This tale reveals that, much like the varied traditions of Christmas around the world, the use of higher dose folic acid in pregnancies among women with ASM-treated epilepsy was quite diverse across these Nordic countries, despite their shared landscapes and healthcare systems. The researchers, acting as Santa’s helpers in the world of science, suggest that future guidelines should be as clear and bright as Rudolph’s nose, developed through the collaborative efforts of neurologists, obstetricians, pediatricians, and public health specialists, to ensure they’re as practical as my sleigh on Christmas Eve.

And so, as we close this chapter, let’s remember the importance of coming together, much like families around the Christmas tree, to ensure the health and well-being of all, especially those embarking on the magical journey of pregnancy. Merry reading, and to all a good night!

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