Discover how the cutting-edge research on long non-coding RNA-NONMMMUT004552.2 unveils its pivotal role in combating unloading-induced bone loss, offering new horizons in functional neurosurgery.
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Long non-coding RNA-NONMMMUT004552.2 regulates the unloading-induced bone loss through the miRNA-15b-5p/Syne1 in mice.
Zhang et al., NPJ Microgravity 2024
<!– DOI: 10.1038/s41526-024-00382-8 //–>
https://doi.org/10.1038/s41526-024-00382-8
This study explores the impact of lncRNA NONMMUT004552.2 on bone loss due to mechanical unloading, a condition simulating microgravity environments like space. The research found that knocking out this lncRNA in mice subjected to hindlimb unloading resulted in increased bone formation and osteoblast activity. Additionally, silencing NONMMUT004552.2 reduced osteoblast apoptosis and altered the expression of key proteins involved in cell survival and death, such as Bax, cleaved caspase-3, and Bcl-2. The study reveals that NONMMUT004552.2 acts as a competing endogenous RNA (ceRNA) that regulates the expression of Syne1 by binding miR-15b-5p, which in turn affects osteoblast differentiation and bone formation under unloading conditions. This mechanism underscores the potential of targeting the lncRNA NONMMUT004552.2/miR-15b-5p/Syne1 axis as a therapeutic strategy for osteoporosis, highlighting a novel aspect of bone biology and offering insights into managing bone loss in microgravity or disuse conditions.