This study aimed to enhance intraoperative MRI (ioMRI) protocols for pediatric brain tumor surgeries by increasing the sensitivity of arterial spin labeling (ASL) and diffusion MRI (dMRI), focusing on patient positioning and radiofrequency (RF) coil setups. The research found that ASL cerebral blood flow (CBF) measurements are consistent between prone and supine positions, indicating the validity of ASL CBF quantification during surgery. Additionally, using four RF coils instead of two significantly improved the signal-to-noise ratio (SNR) for T1-weighted images in both gray (34% increase) and white matter (32% increase), as well as the contrast-to-noise ratio (CNR), without compromising image quality across T1w, T2w, ASL, and dMR images. The four RF coil setup also enhanced image quality and reduced susceptibility artifacts in nonweighted diffusion image maps and corticospinal tract reconstructions. These findings suggest that while ASL and dMRI can be adequately performed with two RF coils for clinical purposes, using four RF coils offers better image precision and reduced artifact sensitivity, which could potentially improve the preservation of healthy tissue during pediatric brain tumor resections.