A novel approach to selecting deep brain stimulation (DBS) targets, the Stereotactic Awake Basal ganglia Electrophysiological Recording and Stimulation (SABERS), was evaluated in a large case series involving 30 children and young adults. This method involves a staged procedure with 8 to 12 temporary depth electrodes for neurophysiological assessment over 5-7 days in an inpatient setting. The aim is to tailor neuromodulation targets to each patient’s functional needs, covering a range of conditions including primary and secondary dystonia, and Tourette syndrome. Following the SABERS protocol, all but one participant received 4 permanent DBS leads, with significant improvements observed in follow-up assessments using the Burke-Fahn-Marsden Dystonia Rating Scale and the Barry-Albright Dystonia Scale. No significant adverse events were reported. This technique represents a significant advancement in functional neurosurgery, offering a method to predict effective stimulation targets across a broad spectrum of brain function disorders, including those with previously unknown optimal targets.