Finite Element (FE) simulations offer a novel approach to enhancing neurosurgical procedures by allowing for the analysis of stress levels within the brain, which are otherwise unmeasurable with current technologies. This study compares the impact of traditional spatulas versus tubular retractors on brain tissue during surgery, highlighting that tubular retractors induce lower stress, particularly in critical areas like the subcortical structures and corpus callosum. It also underscores the significance of the retraction location on stress outcomes. A key finding is the necessity of employing region-specific hyperelastic and viscoelastic parameters in the FE models to accurately simulate the brain’s response during retraction. This research not only aids in optimizing surgical tools and techniques but also stresses the importance of personalized, region-specific modeling for predicting surgical outcomes. Such advancements could significantly contribute to minimizing surgical trauma and improving patient recovery.