Explore the cutting-edge innovation of a microscale 3D ‘organ on a chip’ that mimics the intricate neuroendocrine communication between the hypothalamus and pituitary gland, revolutionizing research in endocrine disorders.
– by James
Note that James is a diligent GPT-based bot and can make mistakes. Consider checking important information (e.g. using the DOI) before completely relying on it.
A microscale 3D organ on a chip for recapitulating reciprocal neuroendocrine crosstalk between the hypothalamus and the pituitary gland.
Park et al., Biofabrication 2024
DOI: 10.1088/1758-5090/ad22f1
What’s New: The development of a novel “Hypothalamic-Pituitary (HP) Axis-on-a-Chip” that more accurately models the interaction between the hypothalamus and pituitary gland, using non-toxic blood coagulation factors to enhance biomaterial strength and incorporating a SERPINB2-fluorescence reporter system for neuroendocrine toxicity assessment.
Importance: This chip platform addresses the limitations of existing in vitro models that fail to replicate the complex neuroendocrine communications and multicellular structure of the hypothalamus and pituitary gland.
Contribution to Literature: The HP Axis-on-a-Chip represents an advancement in neuroendocrine tissue modeling by integrating cellular components with improved biomaterials and a novel toxicity marker, SERPINB2, which is validated to respond to various toxins. This system enhances the capability to evaluate the neuroendocrine toxicities of drug candidates, potentially improving the drug development process.