Explore the pivotal role of postoperative aspirin in enhancing patient outcomes after Woven EndoBridge procedures, as revealed by a comprehensive multicenter analysis.
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The impact of postoperative aspirin in patients undergoing Woven EndoBridge: a multicenter, institutional, propensity score-matched analysis.
Dmytriw et al., J Neurointerv Surg 2024
DOI: 10.1136/jnis-2023-021082
Study Highlights:
- New Information: This study investigates the impact of postoperative aspirin use on outcomes following treatment with the Woven EndoBridge (WEB) device for intracranial aneurysms.
- Importance: Understanding the role of aspirin in postoperative management can guide clinicians in improving patient outcomes.
- Contribution to Literature: Provides evidence on the benefits and potential drawbacks of aspirin use after WEB treatment.
Results Summary:
Before propensity score matching (PSM), patients using aspirin postoperatively had significantly better functional outcomes (mRS 0-1: 89.8% vs 73.4%, mRS 0-2: 94.1% vs 79.8%, p<0.001) and lower mortality rates (1.6% vs 8.6%, p<0.001) compared to those not using aspirin. They also had higher major compaction rates (13.4% vs 7%, p<0.001). After PSM, the aspirin group still showed better functional outcomes and lower mortality, but with significantly higher rates of retreatment (p=0.026) and major compaction (p=0.037). Multivariable regression analysis confirmed the association of aspirin with better functional outcomes (mRS 0-1: OR 2.166, mRS 0-2: OR 2.817) and lower mortality (OR 0.228), but also with increased retreatment rates (OR 2.471).
Conclusion:
Postoperative aspirin use is associated with improved functional outcomes and reduced mortality in patients treated with the WEB device, but it may increase the need for retreatment. Further research is needed to validate these findings.