Explore the pivotal role of Acetazolamide in transforming cerebral hemodynamics for patients grappling with acute brain injuries, as we delve into a comprehensive systematic review.
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The Effects of Acetazolamide on Cerebral Hemodynamics in Adult Patients with an Acute Brain Injury: A Systematic Review.
Stella et al., Brain Sci 2023
DOI: 10.3390/brainsci13121678
Summary of Acetazolamide Effects on Brain Hemodynamics Post-Acute Brain Injury
New Information: This review systematically examines the impact of acetazolamide on cerebral blood flow (CBF), intracranial pressure (ICP), and brain tissue oxygenation (PbtO2) in patients with acute brain injury (ABI).
Importance: Understanding acetazolamide’s effects could inform its therapeutic or diagnostic use in ABI conditions such as subarachnoid hemorrhage, intracerebral hemorrhage, traumatic brain injury, and hypoxic-ischemic encephalopathy.
Contribution to Literature: The review highlights a lack of data on acetazolamide’s effect on ICP and PbtO2. It reveals that cerebral vasomotor reactivity (VMR) to acetazolamide changes during ABI progression, with the lowest response in the subacute stage. Additionally, a correlation between VMR reduction and clinical outcomes was noted.
Results: Out of 3430 records initially identified, only 11 studies were suitable for qualitative analysis. No studies reported on ICP or PbtO2 effects.
Conclusion: There is a scarcity of research on the effects of acetazolamide on brain hemodynamics in ABI patients, indicating a need for further studies to elucidate its potential role.