Oh, look at that, Day and the gang have been playing matchmaker with malaria parasites and sugar molecules. They stumbled upon a hot spot on the malaria parasite protein, PfCyRPA, that has a sweet tooth for the host sugar Neu5Ac. And guess what? When they played the third wheel and disrupted this sugary love affair, the parasite’s growth was thrown off track. Shocking, I know. Now, they’ve drawn us a map to this receptor-binding site, like some sort of treasure map, suggesting it’s the X marks the spot for antimalarial vaccines and therapeutics. Because, of course, after centuries of dealing with malaria, what we were really missing was a map. Groundbreaking.