Dive into the latest findings on how combining recombinant human FSH and LH enhances assisted reproductive technology outcomes for women aged 35-40, offering new hope for those dreaming of parenthood.
– by Klaus
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Effectiveness of recombinant human FSH: recombinant human LH combination treatment versus recombinant human FSH alone for assisted reproductive technology in women aged 35-40 years.
Bielfeld et al., Reprod Biomed Online 2023
<!– DOI: 10.1016/j.rbmo.2023.103725 //–>
https://doi.org/10.1016/j.rbmo.2023.103725
Ho, ho, ho! Gather around, my dear friends, for I have a tale to tell, not of elves and reindeer, but of a quest of a different kind—a quest for the miracle of life. In the land of science and medicine, there lived a group of wise individuals who embarked on a journey to discover the most effective way to help women of advanced maternal age (AMA), those between the ages of 35 and 40, to achieve the dream of motherhood.
In this story, our heroes used a magical potion known as recombinant human FSH (r-hFSH), sometimes combined with another potion, recombinant human LH (r-hLH), to stimulate the gardens of fertility during a process called ART treatment. They sought to find out which combination of potions—r-hFSH alone or r-hFSH with r-hLH—would bring forth the most bountiful harvest of live births.
Using the ancient scrolls from the Deutsches IVF-Register, they observed the outcomes of their enchantments. Initially, it seemed as though both potions were equally potent, with the combined r-hFSH and r-hLH potion and the r-hFSH alone potion leading to similar rates of clinical pregnancy and live births. The numbers were close, with live birth rates at 20.3% for the combined potion and 18.0% for the solo potion, and the differences seemed as slight as the difference between two snowflakes.
But, as in all good tales, there was a twist! Upon closer inspection, specifically among women who had a garden of five to 14 oocytes (a sign of a healthy and normal garden), the combined potion of r-hFSH and r-hLH showed its true power. The rates of clinical pregnancy and live births were significantly higher in this group, shining like a bright star on a dark winter’s night.
So, my dear friends, the moral of our story is that for women of AMA with gardens still full of life, the combined magic of r-hFSH and r-hLH in a 2:1 ratio might just be the key to unlocking their dreams of motherhood. And while the tale reminds us that the gold standard of randomized controlled trials (RCTs) is the best way to assess the effectiveness of treatments, the real-world data from this adventure provides valuable insights, especially for those not usually represented in the grand trials.
As we close this chapter, let us remember that in the quest for creating life, sometimes a combination of magic potions is what it takes to bring forth new joy into the world. And with that, I wish you all a merry journey toward your dreams, filled with hope, science, and a little bit of Christmas magic. Ho, ho, ho!