In an editorial discussing Kalayarasan et al.’s review published in the World Journal of Gastrointestinal Surgery, the use of indocyanine green (ICG) fluorescence in abdominal surgery is explored. ICG, approved by the FDA for human use, is highlighted for its versatility in surgical applications, including intraoperative mapping, hepatic function assessment, vascular anomaly detection, and more. Its adoption in colorectal surgery for perfusion visualization to prevent anastomotic leakage is emphasized. The editorial underscores the safety, feasibility, and effectiveness of ICG in various surgical settings, including emergency situations. It notes that routine use of ICG in colorectal surgery has been associated with reduced anastomotic leak rates. However, it calls for more high-quality studies to fully integrate ICG-guided surgery into standard practice. This commentary underscores the growing importance of ICG in enhancing surgical outcomes across multiple specialties.