Dive into the groundbreaking realm of stem cell transplantation for spinal cord injury, exploring its current achievements and envisioning the future of regenerative medicine in neurosurgery.
– by James
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Current status and future perspectives on stem cell transplantation for spinal cord injury.
Agosti et al., World J Transplant 2024
<!– DOI: 10.5500/wjt.v14.i1.89674 //–>
https://doi.org/10.5500/wjt.v14.i1.89674
A systematic literature review focusing on stem cell therapy for spinal cord injuries (SCI) has been conducted, analyzing 66 studies involving 1086 patients. This review, which spans research up to October 14, 2023, aims to provide a comprehensive overview of clinical trial outcomes, emphasizing both safety and effectiveness. The majority of patients had cervical injuries, and bone marrow stem cells were the most commonly used type (71.1%). The review found that a significant portion of patients experienced functional improvements, with 32.7% moving from American spinal injury association Impairment Scale (AIS) A to B, and 40.8% from AIS A to C. Sensory improvements were reported in 30.9% of patients. Adverse events were relatively few, including fever (15.1%), headaches (4.3%), muscle tension (3.1%), and dizziness (2.6%).
This review highlights the potential of stem cell therapies in SCI recovery but also points out the necessity for careful consideration of transplantation conditions, understanding of SCI pathophysiology, and addressing ethical and safety concerns before widespread clinical adoption.