Discover the pivotal role of glucose-regulatory hormones in the growth of very preterm infants nourished with fortified human milk, shedding light on optimal neonatal nutrition strategies.
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Glucose-regulatory hormones and growth in very preterm infants fed fortified human milk.
Holgersen et al., Pediatr Res 2024
<!– DOI: 10.1038/s41390-024-03166-8 //–>
https://doi.org/10.1038/s41390-024-03166-8
This study explores how fortifying human milk with bovine colostrum (BC) impacts glucose-regulatory hormones in very preterm infants (VPIs), compared to conventional fortifier (CF). Involving 225 VPIs, the research measured plasma hormone levels before and after one and two weeks of fortification, alongside growth metrics up to 35 weeks postmenstrual age. The findings reveal that BC fortification significantly elevates plasma levels of GLP-1, GIP, glucagon, and leptin. Growth correlations showed that prior to fortification, leptin levels were inversely related to growth, whereas IGF-1 levels had a positive association during fortification. Additionally, hormone levels varied with birth weight, showing reduced IGF-1 and leptin in SGA compared to AGA infants. This study highlights the variability of glucose-regulatory hormones in VPIs, influenced by birth weight, fortifier type, and nutritional intake, and underscores the complex relationship between these hormones and early postnatal growth. The research provides new insights into the nutritional management of VPIs, suggesting potential benefits of BC fortification on hormone regulation and growth.