Discover how the NRSN2 gene influences the progression of HPV-related laryngeal cancer by activating autophagy through the AMPK/ULK1 pathway, shedding new light on potential therapeutic targets.
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NRSN2 promotes the malignant behavior of HPV-transfected laryngeal carcinoma cells through AMPK/ULK1 pathway mediated autophagy activation.
Guo et al., Cancer Biol Ther 2024
<!– DOI: 10.1080/15384047.2024.2334463 //–>
https://doi.org/10.1080/15384047.2024.2334463
This study explores the role of Neurensin-2 (NRSN2) in human papillomavirus (HPV)-infected laryngeal carcinoma (LC) cells. It was found that NRSN2 is overexpressed in HPV-transfected LC cells, and its inhibition can significantly reduce autophagy and malignant behaviors such as cell viability, proliferation, invasion, and migration, while increasing apoptosis. The research highlights the AMPK/ULK1 pathway as a critical mediator in this process, with NRSN2 overexpression enhancing autophagy through this pathway. Conversely, inhibiting the AMPK/ULK1 pathway or knocking down NRSN2 suppresses autophagy, thereby limiting the malignant progression of HPV-infected LC cells. This study provides new insights into the pro-carcinogenic role of NRSN2 in LC, particularly in the context of HPV infection, and suggests the NRSN2-AMPK/ULK1 axis as a potential therapeutic target for treating LC.