Explore the critical insights into how sex differences affect coagulation, shedding light on personalized approaches in managing trauma-induced coagulopathy and trauma resuscitation.
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Sex dimorphisms in coagulation: Implications in trauma-induced coagulopathy and trauma resuscitation.
Coleman et al., Am J Hematol 2024
<!– DOI: 10.1002/ajh.27296 //–>
https://doi.org/10.1002/ajh.27296
This review highlights the critical issue of trauma-induced coagulopathy (TIC), a major cause of preventable death in injured patients, emphasizing the need to understand its mechanisms better. A novel perspective is the recognition of a sex-dependent effect on coagulation, where females show a relative hypercoagulability compared to males, even after injury, leading to better outcomes. The review aims to shed light on the mechanisms behind sex differences in coagulation and their protective effect post-injury. It delves into sex dimorphisms across various components of coagulation, including enzymatic hemostasis, fibrinogen, platelets, and fibrinolysis, and discusses their implications for the resuscitation of TIC patients. This exploration is significant as it could guide tailored resuscitation strategies and improve survival rates among injured patients by considering sex-specific coagulation profiles.