The advent of three-dimensional (3D) holograms through mixed-reality (MR) devices marks a significant advancement in the medical field, particularly for preoperative simulations. Unlike traditional 3D images displayed on two-dimensional (2D) monitors, 3D holograms offer a more realistic experience, enabling surgeons to view detailed images directly in their working space without the need to divert their attention to a separate screen. This technology facilitates a more intuitive understanding of complex anatomical structures. Furthermore, when combined with tracking technology, these holograms can be used for 3D augmented reality (AR) navigation during surgeries, providing real-time, precise guidance by overlaying holographic images of targets, such as tumors or aneurysms, onto the patient’s actual anatomy. This innovation not only enhances surgical precision but also opens up possibilities for developing new surgical techniques, including endoscopic and fluoroscopy-guided endovascular surgeries. The integration of 3D holograms into medical procedures represents a forward leap in surgical technology, promising to improve outcomes through more immersive and accurate visualizations.