Discover the critical link between NF2 mutations and the challenging outcomes of psammomatous meningiomas, particularly in spinal locations, shedding light on the complexities of neurosurgical interventions.
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Association of frequent NF2 mutations with spinal location predominance and worse outcomes in psammomatous meningiomas.
Ren et al., J Neurosurg 2024
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https://doi.org/10.3171/2024.1.JNS232450
This study delves into Psammomatous meningiomas (PMs), a rare subtype of meningioma, focusing on their incidence, clinical features, molecular alterations, and prognostic factors. Out of 151 patients analyzed, PMs were found to be more common in spinal locations and among females. A notable finding was the high rate of calcification (88.24%) in PMs. Molecular analysis highlighted NF2 as the most frequently mutated gene (59.7%), with significant differences between spinal PMs (SPMs) and cranial PMs (CPMs); NF2 mutation was present in all SPMs but only 38.46% of CPMs. Factors such as age, extent of resection, Ki-67 index, and NF2 status were identified as independent prognostic indicators. The study underscores the unique clinical and molecular characteristics of PMs, especially the association of NF2 mutations with spinal location and poorer progression-free survival, offering new insights into their management and prognosis.