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Association of decreased estimated glomerular filtration rate with lung cancer risk in the Korean population.
Shin et al., Epidemiol Health 2024
<!– DOI: 10.4178/epih.e2024041 //–>
https://doi.org/10.4178/epih.e2024041
This study investigates the link between low estimated glomerular filtration rate (eGFR) and lung cancer risk among the Korean population, utilizing data from 358,293 adults from the National Health Insurance Service-National Sample Cohort (2009-2010). Participants were divided into three groups based on eGFR levels: group 1 (eGFR ≥90 mL/min/1.73m2), group 2 (eGFR ≥60 to <90mL/min/1.73m2), and group 3 (eGFR <60 mL/min/1.73m2). The study found that group 2 had a 26.5% higher risk (HR, 1.265; 95% CI, 1.189 to 1.346) and group 3 had a 72.5% higher risk (HR, 1.725; 95% CI, 1.577 to 1.887) of developing lung cancer compared to group 1. Moreover, individuals in group 3 with significant proteinuria (dipstick proteinuria of 2+ or greater) exhibited an even higher risk (HR, 2.928; 95% CI, 1.375 to 6.237). This highlights a significant association between low eGFR and increased lung cancer risk, especially among those with severe proteinuria, underscoring the importance of further research in this area.