Dive into the critical insights on how obesity impacts blood flow dynamics in individuals suffering from Cushing’s Disease, shedding light on potential therapeutic avenues.
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Obesity-Related Hemodynamic Alterations in Patients with Cushing’s Disease.
Jurek et al., J Clin Med 2024
<!– DOI: 10.3390/jcm13061658 //–>
https://doi.org/10.3390/jcm13061658
Study Highlights Obesity’s Impact on Heart Function in Cushing’s Disease Patients
This study investigates the hemodynamic profile of 54 newly diagnosed Cushing’s disease (CD) patients without significant comorbidities, focusing on the effects of obesity on cardiovascular function. Using impedance cardiography (ICG) and applanation tonometry, alongside echocardiography, the research reveals that CD patients with obesity (BMI ≥ 30 kg/m2) exhibit notably impaired heart pumping function compared to non-obese CD patients. Specifically, obese patients showed significantly lower values in velocity index (VI: 37.0 ± 9.5 vs. 47.2 ± 14.3 × 1*1000-1*s-1, p=0.006), acceleration index (ACI: 58.7 ± 23.5 vs. 76.0 ± 23.5 × 1/100/s2, p=0.005), and Heather index (HI: 11.1 ± 3.5 vs. 14.6 ± 5.5 × Ohm/s2, p=0.01). Echocardiography indicated larger heart chamber sizes and increased left ventricular mass index in obese patients, although no significant differences in blood pressure, heart rate, left ventricular ejection fraction (LVEF), global longitudinal strain (GLS), total arterial compliance index (TACI), central pulse pressure (CPP), or augmentation index (AI) were observed.
Importance: This study underscores the early hemodynamic alterations associated with obesity in CD patients, highlighting the need for targeted cardiovascular assessments and interventions in this population.