Discover how a unique lifestyle intervention, with and without the addition of protein drinks, impacts inflammation in older adults battling obesity and type 2 diabetes, shedding new light on managing these conditions.
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The effect of a combined lifestyle intervention with and without protein drink on inflammation in older adults with obesity and type 2 diabetes.
Memelink et al., Exp Gerontol 2024
<!– DOI: 10.1016/j.exger.2024.112410 //–>
https://doi.org/10.1016/j.exger.2024.112410
This study explored the impact of a 13-week combined lifestyle intervention, incorporating a hypocaloric diet and exercise (resistance and high-intensity interval training), on the chronic low-grade inflammatory profile (CLIP) in older adults with type 2 diabetes (T2D), with an additional focus on the effects of a protein drink. Analyzing data from the PROBE study, which included 114 adults aged 55 years and older with obesity and T2D, the research found no significant difference in CLIP responses between participants who consumed the protein drink and those who did not. Key findings include a decrease in anti-inflammatory cytokine IL-1RA and adipokines leptin and adiponectin, alongside an increase in inflammatory ratios TNF-α/IL-10 and TNF-α/IL-1RA. Interestingly, CRP levels increased by 12% in participants with low to average CLIP but decreased by 36% in those with high CLIP. Changes in leptin and IL-1RA were positively associated with changes in fat mass and insulin resistance, but not with lean mass. This study highlights the nuanced effects of lifestyle interventions on inflammation in T2D, suggesting that baseline inflammatory status may influence outcomes.