Discover how Dendrobium officinale Polysaccharide (DOP) offers a promising new approach to soothing psoriasis by targeting cell hyperproliferation, inflammation, and oxidative stress in our latest dermatology insights.
– by Marv
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Dendrobium officinale Polysaccharide (DOP) inhibits cell hyperproliferation, inflammation and oxidative stress to improve keratinocyte psoriasis-like state.
Zeng et al., Adv Med Sci 2024
<!– DOI: 10.1016/j.advms.2024.03.005 //–>
https://doi.org/10.1016/j.advms.2024.03.005
Oh, gather round, skincare aficionados and science enthusiasts, for I have a tale that’s as refreshing as aloe on sunburnt skin. It’s the story of how the mighty Dendrobium officinale polysaccharide (let’s call it DOP because we’re all friends here) swooped in to save the day in the world of keratinocytes behaving badly—aka psoriasis.
In the land of “let’s poke cells and see what happens,” researchers decided to throw a party with some HaCaT keratinocytes. But not just any party—it was a psoriasis-like model party. They invited some notorious guests: interleukin (IL)-22 and lipopolysaccharide (LPS) to stir up inflammation, and H2O2 to crank up the oxidative stress. It was, as you can imagine, quite the rager.
Enter our hero, DOP, caped and ready to calm the chaos. But first, a test! The researchers wanted to make sure DOP wasn’t just another wallflower. They checked if it could mingle without causing a scene among the normal keratinocytes. And guess what? DOP was as chill as they come—no unwanted cell proliferation here.
But when it came to the party crashers causing inflammation and oxidative stress, DOP was on it like white on rice. It told IL-22-induced overproliferating keratinocytes to take a chill pill, reducing their numbers and telling proliferation-related factors (PCNA, Ki67, Cyclin D1) and the AKT pathway to simmer down.
And inflammation? DOP was like, “Not in my house,” putting a stop to the inflammatory gossip spread by IL17A, IL-23, IL1β, TNF-α, and IL-6. Oxidative stress didn’t stand a chance either, with DOP lowering the ROS levels and boosting the skin cell’s own antioxidants.
In the end, DOP emerged as the hero, inhibiting keratinocyte hyperproliferation, inflammation, and oxidative stress, thereby improving the keratinocyte psoriasis-like state. It’s like DOP walked out of the lab, dropped the mic, and said, “That’s how you do skincare science, folks.”
So, there you have it—a tale of how a humble polysaccharide could potentially offer relief to those keratinocytes caught in the throes of psoriasis, all thanks to the magic of poking cells in a lab. Science, isn’t it grand?