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Evaluation of renal tubular function by multiparametric functional MRI in early diabetes.
Wang et al., Magn Reson Imaging 2024
<!– DOI: 10.1016/j.mri.2024.03.016 //–>
https://doi.org/10.1016/j.mri.2024.03.016
This study evaluates renal tubular function in a type 1 diabetes mellitus (DM) rabbit model using MRI techniques, focusing on renal oxygenation (R2*), oxygen extraction fraction (OEF), and renal blood flow (RBF). The research involved 26 rabbits divided into two groups based on the duration of DM (3-day and 7-day). The study utilized multiparametric MRIs before and after furosemide injection to assess changes in renal parameters and correlated these with pathological kidney injury scores.
Key findings include:
– A significant decrease in medullary R2* and OEF after furosemide administration at baseline, indicating normal tubular response.
– In both DM groups, this response was diminished, suggesting tubular dysfunction early in DM.
– No significant change in medullary RBF was observed.
– A strong correlation between pathological tubular injury scores and changes in medullary R2* and OEF (r=0.82 for both).
Importance: This study demonstrates that MRI measurements of medullary OEF and R2* in response to furosemide can detect early renal tubular dysfunction in DM, contributing to the understanding of DM-related renal impairment.