Discover how Systemic Lupus Erythematosus significantly elevates the risk of spontaneous preterm births, shedding light on crucial findings from a comprehensive systematic review and meta-analysis.
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Systemic Lupus Erythematosus is Associated With an Increased Frequency of Spontaneous Preterm Births: Systematic Review and Meta-analysis.
Abheiden et al., Am J Obstet Gynecol 2024
<!– DOI: 10.1016/j.ajog.2024.03.010 //–>
https://doi.org/10.1016/j.ajog.2024.03.010
This study highlights the significant risk of both spontaneous and indicated preterm birth (PTB) in women with systemic lupus erythematosus (SLE). Through a comprehensive systematic literature search and meta-analysis of 21 articles, involving 8157 pregnancies in women with SLE, it was found that on average, 31% of these pregnancies resulted in PTB. Specifically, 14% were spontaneous PTBs, and 16% were indicated PTBs. This distinction is crucial as the risk of spontaneous PTB in SLE pregnancies is less recognized compared to the well-known risk of indicated PTB due to hypertensive disorders or fetal growth restriction. The findings underscore the importance of incorporating this risk into pre-pregnancy counseling and pregnancy management for women with SLE. Moreover, this study sets the stage for future research aimed at identifying risk factors and developing interventions to reduce the rate of spontaneous PTB among pregnant women with SLE.