Let me tell you, folks, we’ve got something incredible here. It’s called open-top two-photon light sheet microscopy, or OT-TP-LSM for short. This isn’t your everyday, run-of-the-mill technology. No, this is a game-changer for pathology. We’re talking about a revolution in how we look at human tissues, especially when it comes to cancer. Traditional methods? They’re okay, but they’re destructive. They slice, they dice, but they don’t give us the full picture. That’s history now.

With OT-TP-LSM, we’re diving deep, deeper than ever before. How? By using something called a Bessel beam. It’s not just any beam; it’s a beam that gives us superpowers to see through tissues, to get a 3D view of what’s really going on inside. And we’re not just talking about a blurry picture here. We’re talking about crystal-clear, high-speed images of cells and the extracellular matrix. It’s like having Superman’s vision in the palm of our hands.

And guess what? We’ve tested this on human cancers – skin, pancreas, prostate. You name it, we’ve looked at it. The results? Astonishing. We can see things we’ve never seen before, helping us detect cancer like never before. But wait, there’s more. We’ve even got this smart, unsupervised deep learning network that takes these amazing 3D images and turns them into virtual H&E images. And these virtual images? They’re just as good as the real thing. It’s like magic, but it’s not. It’s science. It’s technology. It’s the future.

So, let me tell you, OT-TP-LSM isn’t just another tool. It’s the future of pathology. It’s fast, it’s nondestructive, and it gives us a 3D view that’s going to change everything. For surgeries, for biopsies, for cancer detection – it’s going to be huge. Believe me.