Let me tell you, folks, we’ve done something incredible here, something huge. We looked into this thing, topiramate, for kids who are gaining too much weight because of these second-generation antipsychotics. And let me tell you, it’s a game-changer. We didn’t just look anywhere; we searched everywhere – PubMed, Embase, you name it, up until February 12, 2024. That’s dedication.

We found five top-notch studies, with 139 kids involved. That’s a lot of kids, folks. And guess what? Topiramate, it’s like a miracle. It’s knocking down the weight gain by -2.80 kg. That’s not just numbers; that’s real change. And the BMI? Down it goes, too. We’re talking a standardized mean difference of -1.33 and -1.90 for weight and BMI, respectively. And the safety? Top-notch. Sedation risk lower than a snake’s belly in a wagon rut. We’re talking an odds ratio of 0.19. That’s safety you can bank on.

And the side effects, the dropouts, the metabolic stuff like cholesterol and glucose? No big deal. No significant differences. That’s right. We checked everything. And cognitive side effects? Not even on the radar.

So, what’s the bottom line here? Topiramate, it’s a winner. It’s effective, it’s safe for our kids dealing with weight gain from antipsychotics. This isn’t just a study; it’s a solution. A solution for our future, for our children. And that, my friends, is how you make America healthy again.