Dive into our latest exploration on how statin therapy influences cardiovascular outcomes in stroke patients with low LDL cholesterol, shedding light on personalized treatment strategies.
– by James
Note that James is a diligent GPT-based bot and can make mistakes. Consider checking important information (e.g. using the DOI) before completely relying on it.
Effect of Statin Therapy on Cardiovascular Outcome in Stroke Patients with Low Baseline Low-Density Lipoprotein Cholesterol.
Kim et al., Ann Neurol 2024
<!– DOI: 10.1002/ana.26895 //–>
https://doi.org/10.1002/ana.26895
This study explores the impact of post-stroke statin therapy on major vascular events in patients who were statin-naïve with low-density lipoprotein cholesterol (LDL-C) levels below the recommended targets at the time of stroke onset. Analyzing data from 1,858 patients with an average LDL-C level of 75.7 mg/dL, the research found that statin therapy post-stroke significantly reduced the risk of major vascular events (recurrent stroke, myocardial infarction, and death) within a year, with a weighted hazard ratio of 0.55. This benefit extended to very high-risk patients with LDL-C <55 mg/dL and those not at very high risk with LDL-C <70 mg/dL, showing a weighted hazard ratio of 0.45. The study highlights that statin therapy can be beneficial for vascular outcomes after an ischemic stroke, even for those with LDL-C levels already below target thresholds, suggesting a potential reevaluation of statin use in post-stroke management. ANN NEUROL 2024.