This study aims to explore the use of PET imaging with 18F-FDG and 68Ga-DOTANOC tracers for assessing arterial wall inflammation in unruptured intracranial aneurysms (UIA), a novel application in this field. It involves enrolling patients scheduled for UIA surgery, who will undergo PET imaging of intracranial arteries, alongside other diagnostic procedures like MRI and CT, within a month before their surgery. The study will also collect preoperative blood samples, intraoperative cerebrospinal fluid samples, and aneurysm sac biopsies from a planned sample size of at least 18 patients. The primary outcome focuses on the uptake of the tracers in UIAs compared to normal vessels and their correlation with histological findings. Secondary outcomes aim to correlate tracer uptake and histological findings with various clinical and biological parameters. Approved by relevant ethics committees, the study’s results will be shared through scientific publications and conference presentations. This research could significantly contribute to understanding the inflammatory processes in UIA and potentially offer a new diagnostic tool.