Explore the groundbreaking insights into the immune system’s role in kidney health with our deep dive into the T-Cell receptor repertoire in IgA nephropathy.
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Characterization of T-Cell receptor repertoire in immunoglobulin a nephropathy.
Ho et al., Biomark Res 2024
<!– DOI: 10.1186/s40364-024-00572-2 //–>
https://doi.org/10.1186/s40364-024-00572-2
New Information: This study identifies potential non-invasive biomarkers for the diagnosis of Immunoglobulin A nephropathy (IgAN) by analyzing the characteristics of the T cell repertoire in peripheral blood samples.
Importance: The research offers an alternative to renal biopsy, which is the current standard for IgAN diagnosis but is invasive and carries risks.
Contribution to Literature: The study contributes to the understanding of the immune system’s role in IgAN and suggests that T cell receptor (TCR) repertoire characteristics could serve as diagnostic biomarkers.
Results Summary: The study included 8 IgAN patients, 25 non-IgAN patients, and 10 healthy controls. It was found that IgAN patients had a reduced diversity in their TCRβ repertoire and a distinct usage pattern of five TRBV genes, especially TRBV6-4, which is linked to mucosal-associated invariant T (MAIT) cells and was used more frequently in IgAN patients. These findings suggest that TCR repertoire characteristics, particularly the involvement of MAIT cells, could be indicative of IgAN.