Listen, folks, we’ve got to talk about something that’s getting more and more popular – it’s the use of cannabis, for medical reasons, for fun, it’s everywhere. But hold on, we’ve got to think about our bones, our health. There’s been some trials, sure, but they’re giving us mixed signals, believe me. We need to know more, we need to understand what’s happening with our bones when we’re using this stuff.

So, we did something tremendous, we looked into it. We took a look at cannabidiol, CBD, and Δ9-tetrahydrocannabinol, THC, in different doses, and we put them to the test with human bone cells. We’re talking about real human osteoclasts and osteoblasts, the best of the best. And what we found – it’s interesting, I’ll tell you that.

THC and CBD, they’re doing something to our bones. In small doses, they’re not messing with the fusion of osteoclasts, but they’re making them work harder, resorbing bone. But when you ramp up the dose, they put the brakes on – they stop both the fusion and the resorption. And when we put these cells together, in co-cultures, both the bone-eating activity and the bone-building signals go down.

And here’s something – we’ve got these receptors, CNR1 and CNR2, and it turns out CNR2 is the big player in these bone cells. But as these cells turn into osteoclasts, CNR2 goes down. And in the co-cultures, CNR2 is the only one showing up to the party.

What we’re seeing here, it’s both good and bad, it’s not black and white. Cannabinoids, they can do things to your bones that you might not want. It’s complicated, and we’ve got to be smart about it. So, when you’re thinking about using cannabis, for whatever reason, remember – it’s not just about feeling good, it’s about staying strong, staying healthy. We’ve got to consider everything, and that’s what we’re doing, we’re making sure we know what’s going on.