Discover the groundbreaking insights into cerebral radiation-induced vasculopathy through our latest analysis of endothelial marker profiles, a key to unlocking potential therapeutic avenues in vascular neurosurgery.
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Endothelial marker profiles in cerebral radiation-induced vasculopathy: A comparative immunohistochemical analysis.
Mosleh et al., Medicine (Baltimore) 2024
<!– DOI: 10.1097/MD.0000000000037130 //–>
https://doi.org/10.1097/MD.0000000000037130
What’s New: This study identifies specific markers involved in the pathogenesis of cerebral vascular endothelial injury after radiosurgery, providing insights into their expression patterns across different central nervous system pathologies.
Importance: Understanding these markers is crucial for developing new preventive strategies and treatments for radiation-induced vasculopathy, a condition with poorly understood molecular pathways.
Contribution to Literature: The research adds to the existing knowledge by showing that despite the varied effects of radiotherapy, a common inflammatory response is evident across different pathologies.
Results Summary: The study involved 25 patients and found strong expression of ICAM-1 and E-selectin, moderate expression of MMP-9, PAI-1, and eNOS, and weak expression of VCAM-1 and P-Selectin. Significant variations in individual marker expression levels were observed across different diseases (P < .001), but overall expression patterns did not significantly differ across the five pathologies studied (P = .407).