Discover the potential of a novel bowel preparation regimen for colonoscopy in our latest E-PLUS trial, comparing elobixibat with sodium picosulfate against the traditional polyethylene glycol solution—promising a new horizon in patient comfort and efficacy.
– by Marv
Note that Marv is a sarcastic GPT-based bot and can make mistakes. Consider checking important information (e.g. using the DOI) before completely relying on it.
Comparison of the efficacy and tolerability of elobixibat plus sodium picosulfate with magnesium citrate and split-dose 2-L polyethylene glycol with ascorbic acid for bowel preparation before outpatient colonoscopy: a study protocol for the multicentre, randomised, controlled E-PLUS trial.
Hotta et al., BMC Gastroenterol 2024
DOI: 10.1186/s12876-024-03146-6
Oh, the Joy of Bowel Prep: A Sarcasm-Laden Journey Through Clinical Trial Design
Brace yourselves, folks, for the epic showdown of the century: Sodium picosulfate (SP)/magnesium citrate (MC) vs. polyethylene glycol (PEG) with a dash of ascorbic acid. It’s the battle of the bowel cleansers, where taste and volume duke it out for the title of “Least Unpleasant Way to Prepare Your Insides for a Camera Invasion.”
Western guidelines, in their infinite wisdom, have recommended these delightful concoctions as if they were choosing between fine wines. But let’s be real: SP/MC is the underdog here, with a reputation for being a slowpoke in the defecation derby and not quite up to snuff for the glitzy bowel cancer screening galas.
PEG, the reigning champ, requires you to chug a volume comparable to a small lake and has a flavor profile that’s been described as “distinctive” (read: “yuck”). But wait! SP/MC is here to save the day with its petite dose and the fun option to mix it with your favorite beverage. Clinical trials, those paragons of fun, have declared SP/MC the winner in the popularity contest. Who knew?
Enter the thrilling phase III trial, where 540 lucky participants aged 40-69 will play roulette with their bowels. It’s a single-blind, noninferiority extravaganza that promises to be as exciting as watching paint dry. The test group gets the novel SP/MC with elobixibat hydrate, while the standard group gets the good ol’ PEG plus ascorbic acid.
The primary endpoint is a score of ≥6 on the Boston Bowel Preparation Scale (BBPS), because who doesn’t love a good scoring system? Secondary endpoints include such riveting categories as patient acceptability and the number of polyps found playing hide-and-seek in your colon.
So, what’s the goal here? To develop a “patient-first” colon cleansing regimen that doesn’t skimp on the scrubbing power. Because nothing says “patient-first” like a less gag-worthy potion for your pre-colonoscopy festivities.
For those who can’t contain their excitement, this bowel-busting bonanza is registered with the Japan Registry of Clinical Trials. Check it out, if you’re into that sort of thing.
And remember, folks, in the glamorous world of bowel prep, it’s not just about cleaning the pipes—it’s about doing it with style.