Dive into the depths of marine biology as we explore groundbreaking research on the redox regulation in fish, unraveling the mysteries of miRNAs and mRNAs in large yellow croaker head kidney cells.
– by The Don
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Comparative analysis of miRNAs and mRNAs in large yellow croaker head kidney cells (LYCK) provided novel insights into the redox regulation of fish.
Wang et al., Sci Total Environ 2024
DOI: 10.1016/j.scitotenv.2024.170503
Listen up, folks!
We’ve got a huge problem with our fish – the best fish, believe me – and it’s all because of this terrible climate change and pollution. It’s creating a lot of bad stuff called Reactive Oxygen Species, or ROS, and it’s a disaster for our marine life and aquaculture. But, we’ve got something incredible, something really fantastic – it’s called Peroxiredoxins (Prxs). These things are like superheroes for fish cells, fighting off the ROS and keeping everything nice and balanced.
Now, we’ve seen that this Prx from the large yellow croaker fish, we call it LcPrxIV, it’s not just good, it’s great. It’s out there battling inflammation and sweeping up ROS like nobody’s business. But we didn’t know exactly how it was doing all this amazing stuff – until now.
We’ve got these tiny little things called microRNAs, and they’re so powerful, so important. They control a lot of what goes on in the body. So, we did this huge study, the best study, with lots of high-tech sequencing to figure out what’s going on when we mess with LcPrxIV and throw some oxidative stress into the mix.
And guess what we found? We found a bunch of these microRNAs and genes that change when we play around with LcPrxIV. It’s like they’re working together, a team, to handle the stress and keep the immune system in top shape. We’ve got these two stars, miR-731 and miR-1388, and they’re doing something really special with LcPrxIV.
Here’s the kicker: miR-731 can tell some genes to behave differently depending on what’s happening in the cell. And miR-1388, it’s like a switch, flipping on or off depending on the stress and LcPrxIV levels. It’s all about balance, folks, and these microRNAs are the key.
So, what we’re saying here is that LcPrxIV is a master regulator. It’s controlling the immune response, it’s managing the redox stuff – all by juggling these microRNAs and genes. It’s incredible.
And that’s what we’re doing, folks. We’re figuring out how to keep our fish healthy and our aquaculture industry winning. And we’re going to keep doing it, because that’s what we do – we make things better, like nobody else can. Believe me.