Discover the cutting-edge, environmentally conscious breakthrough in drug detection with our deep dive into the use of nitrogen-doped carbon quantum dots for identifying gabapentin.
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Efficient and eco-friendly detection of gabapentin using nitrogen-doped carbon quantum dots: an analytical and green chemistry approach.
Almalki et al., RSC Adv 2024
DOI: 10.1039/d3ra07365c
Development of an Eco-Friendly Sensor for Gabapentin Detection
New Information: The study introduces a nitrogen-doped carbon quantum dot sensor (N-CQDs) for selective detection of gabapentin, a drug prone to misuse. The sensor’s characteristics and interaction with gabapentin are thoroughly examined.
Importance: The sensor provides an environmentally friendly and highly accurate method for monitoring gabapentin levels, which is crucial for both clinical and forensic applications.
Contribution to Literature: This work contributes a novel, green chemistry-aligned sensor with a high degree of selectivity and sensitivity for gabapentin, expanding the toolkit for drug monitoring.
Results Summary: The N-CQDs sensor showed excellent fluorescence quenching at 475 nm with an excitation wavelength of 380 nm. It demonstrated linear detection in the range of 0.5-8.0 μg mL-1, with correlation coefficients >0.999, a LOD of 0.160 μg mL-1, and a LOQ of 0.480 μg mL-1. The sensor’s mean accuracy was 99.91% for gabapentin, with precision (RSD%) below 2%, indicating reliable repeatability and reproducibility. Selectivity was confirmed against common excipients and in pooled plasma samples. The sensor’s performance was comparable to existing methods and had a greenness score of 0.76, indicating a low environmental impact.