Discover the potent anti-cancer properties of Clerodendrum infortunatum L. root extracts, as new research unveils their remarkable ability to halt the growth of Hepatocellular Carcinoma cells.
– by James
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Polyphenol Mediated Suppression of Hepatocellular Carcinoma (HepG2) Cell Proliferation by Clerodendrum infortunatum L. Root.
Ranatunge et al., Asian Pac J Cancer Prev 2024
DOI: 10.31557/APJCP.2024.25.1.351
Study Highlights:
- The study validates the traditional use of Clerodendrum infortunatum L. root extract (AECIR) for cancer treatment.
- AECIR showed significant antioxidant activity, with EC50 values of 350.2 ± 1.5 μg/mL for DPPH, 19.7 ± 2.3 μg/mL for HO•, 11.7 ± 0.1 μg/mL for H2O2, and 273.1 ± 0.9 μg/mL for •NO scavenging.
- The extract exhibited a dose- and time-dependent antiproliferative effect on HepG2 liver cancer cells with an EC50 of 239.1 ± 1.3 μg/mL, while being non-toxic to normal rat fibroblast cells (CC1) with an EC50 of 1062.7 ± 3.4 μg/mL.
- Removal of polyphenols from AECIR resulted in a significant decrease in both antioxidant activity and HepG2 cell viability, highlighting the importance of polyphenols.
- Apoptosis induction in HepG2 cells by AECIR was confirmed through EB/AO uptake, mitochondrial transmembrane potential depletion, and DNA fragmentation assays.
Importance:
This research provides scientific backing for the anticancer properties of AECIR, particularly through the activation of the apoptotic pathway in liver cancer cells. It emphasizes the role of polyphenols in the extract’s effectiveness, contributing to the understanding of how traditional remedies can be integrated into modern cancer therapies.