Discover the groundbreaking strides in neuronavigation as we delve into the latest all-ultrasound cranial imaging method and its pivotal role in enhancing the precision of focused ultrasound therapy in non-human primates.
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An all-ultrasound cranial imaging method to establish the relationship between cranial FUS incidence angle and transcranial attenuation in non-human primates in 3D.
Singh et al., Sci Rep 2024
DOI: 10.1038/s41598-024-51623-5
Advancements in Focused Ultrasound (FUS) for Drug Delivery Across the Blood-Brain Barrier
New Information: This study introduces a method for calculating the incidence angle of FUS beams in 3D using harmonic ultrasound imaging, which avoids ionizing radiation. This technique is applied to non-human primate (NHP) skull fragments and in-vivo NHPs, demonstrating its capability to accurately identify skull features and confirming the relationship between incidence angle and FUS beam attenuation.
Importance: The ability to calculate the FUS beam incidence angle in 3D is crucial for optimizing the non-invasive opening of the blood-brain barrier (BBB) to enhance drug delivery. This method improves upon previous 2D calculations that relied on CT scans, offering a safer and potentially more accurate alternative.
Contribution to Literature: The study contributes to the field by providing a non-ionizing imaging alternative for FUS applications, which could lead to broader adoption of FUS technology. It also validates the relationship between incidence angle and FUS effectiveness, which is essential for clinical applications.
Numerical Details: The study does not provide specific numerical results but confirms the previously reported correlation between incidence angle and FUS beam attenuation.