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A patient alive without disease 32 months after conversion surgery following lenvatinib treatment for hepatocellular carcinoma with a tumor thrombus originating in the middle hepatic vein and reaching the right atrium via the suprahepatic vena cava: a case report.
Gyoda et al., Clin J Gastroenterol 2024
DOI: 10.1007/s12328-023-01909-4
Key Points:
– A 75-year-old man with a large hepatocellular carcinoma (HCC) and tumor thrombus underwent successful conversion surgery after treatment with lenvatinib.
– The tumor, initially 108 mm, shrank to 72 mm after 19 months of lenvatinib, and the tumor thrombus receded.
– The patient remained disease-free 51 months after starting treatment and 32 months post-surgery.
Importance:
This case highlights the potential of lenvatinib, a molecular target drug, to downsize initially unresectable HCC to enable surgical intervention, which can lead to long-term survival.
Contribution to Literature:
The report adds to the limited data on long-term outcomes of conversion surgery for HCC following treatment with new molecular target drugs and immune checkpoint inhibitors, suggesting a promising role for this combined treatment strategy in managing advanced HCC.