Let me tell you, folks, we’ve got something incredible here. It’s about how our bodies fight against transplanted organs, and believe me, it’s all about these innate immune cells. They’re tremendous, really tremendous. The moment an organ is put in, these monocytes, they just rush in there, and they turn into these big, inflammatory macrophages. It’s huge, the way they start the inflammation in the new organ.

But here’s the thing, we didn’t know what was making them do that. Now, we’ve found out it’s this thing called AXL. It’s a key player, a real driver. When there’s a new organ, AXL tells these monocytes to go in and get tough, to become those big, inflammatory macrophages. And they’re not just sitting there; they’re presenting the foreign tissue to T cells, getting them all riled up. It’s a big deal, folks.

Now, hold on, because this is where it gets really good. We’ve got this drug, bemcentinib, and it’s like nothing else. You use it early on, just for a short time, and it’s like magic. It calms everything down, reduces the inflammation, and the organ, it lasts way longer. It’s a game-changer. We’re talking about a huge improvement in how we handle transplants. So, we’re going to look into this AXL thing a lot more. It could be part of the best treatment plan ever. It’s going to be great, really great.