Explore the intricate landscape of glioblastoma through a groundbreaking 3D whole-tumor analysis, unveiling the evolution and heterogeneity of one of the most aggressive brain cancers.
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Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspective.
Mathur et al., Cell 2024
DOI: 10.1016/j.cell.2023.12.013
What’s New: This study introduces a novel approach to understanding glioblastoma (GBM) heterogeneity and evolution by using 3D neuronavigation to collect and map tumor samples. The research provides a comprehensive 3D spatial analysis of the tumor’s genomic, epigenomic, and microenvironmental diversity.
Importance: GBM treatment often fails due to the tumor’s complex heterogeneity and evolution. This study’s findings offer insights into the tumor’s evolutionary trajectories and the spatial distribution of genetic and microenvironmental variations, which are crucial for developing targeted therapies.
Contribution to Literature: The research contributes to the current understanding of GBM by distinguishing between tumor-wide molecular features and those specific to certain regions. It also identifies potential therapeutic targets to overcome treatment resistance. The study’s interactive platform for 3D visualization and analysis of GBM represents a significant advancement in the field, potentially guiding more effective treatment strategies.