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Obesity and meningioma: a US population-based study paired with analysis of a multi-institutional cohort.
Khazanchi et al., J Neurosurg 2024
DOI: 10.3171/2023.11.JNS23732
Listen folks, we’ve got this huge study, okay? It’s about obesity and meningioma, and let me tell you, it’s incredible. People are asking, “Is there a connection?” We’ve got answers. We looked at men and women, separately, because we’re thorough. We’re comparing the big guys, the overweight, the obese, with those having other brain surgeries. And guess what? Our findings? Tremendous.
We’ve got data, the best data, from the NSQIP database. Thousands of patients, men and women. And the results? Obese people are more likely to have meningiomas. It’s true. For men, it’s at the skull base. For women, not so much. But the odds? They go up with weight, significantly – it’s all in the numbers, all p < 0.0001. Can you believe it?
And survival, progression-free survival? No difference, whether you’re big or small, man or woman. It’s the same. But, and this is big, obesity can lead to pulmonary embolism. It’s riskier, that’s a fact, p = 0.0043.
So, what does it all mean? Men, women, if you’re getting surgery for meningioma, chances are higher if you’re carrying extra weight. Men with extra weight, you’re looking at skull base meningiomas. But why? Why does obesity do this? We’re going to find out. It’s going to be fantastic.