Explore the cutting-edge of pediatric cancer treatment with our deep dive into the latest immunotherapy strategies, including CAR-T cells, BiTEs, and oncolytic viruses, revolutionizing the fight against colorectal cancer in children.
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New immunotherapy approaches for colorectal cancer: focusing on CAR-T cell, BiTE, and oncolytic viruses.
Kamrani et al., Cell Commun Signal 2024
DOI: 10.1186/s12964-023-01430-8
Emerging Immunotherapy Approaches for Colorectal Cancer
What’s New: The review highlights innovative immunotherapy strategies being explored for colorectal cancer, which is a leading cause of cancer-related deaths globally. Traditional treatments like chemotherapy and surgery have limitations and side effects, prompting the need for better alternatives.
Importance: Immunotherapy represents a promising frontier in colorectal cancer treatment, potentially offering more effective and less harmful options compared to conventional therapies.
Contributions to Literature: The review discusses cutting-edge immunotherapies such as:
- Immune checkpoint inhibitors that block proteins preventing the immune system from attacking cancer cells.
- CAR-T cell therapy, which involves engineering patient’s T cells to better fight cancer.
- BiTEs (bispecific T-cell engagers) that help T cells recognize cancer cells.
- Tumor-infiltrating lymphocytes (TILs) extracted from the tumor, expanded in the lab, and reintroduced into the patient.
- Oncolytic virus therapy, using viruses that selectively infect and kill cancer cells.
Additionally, the review covers the potential of combination therapies, precision medicine approaches, biomarker discovery for tailored treatments, strategies to overcome resistance to immunotherapies, and managing immune-related side effects.
Video Abstract: A visual summary is provided to enhance understanding of the content.