Discover how cutting-edge optical tracking is revolutionizing transcranial focused ultrasound procedures with personalized acoustic simulations, enhancing precision in non-invasive neurotherapies.
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Generating Patient-Specific Acoustic Simulations for Transcranial Focused Ultrasound Procedures Based on Optical Tracking Information.
Sigona et al., IEEE Open J Ultrason Ferroelectr Freq Control 2023
DOI: 10.1109/ojuffc.2023.3318560
Summary of New Findings:
The study introduces a new software pipeline that integrates optical tracking data with acoustic simulations to improve the accuracy of transducer positioning in transcranial focused ultrasound (tFUS) procedures. This method accounts for subject-specific skull characteristics, which are typically not considered in optical tracking alone.
Importance:
This advancement is significant because it enhances the precision of tFUS, which is crucial for the safety and efficacy of the procedure. The software can replicate the geometry of tFUS within the optical tracking system’s limits, with a transcranial target registration error (TRE) of 3.9 ± 0.7 mm. It also demonstrates the potential to reduce the TRE significantly to 1.1 ± 0.4 mm by updating the transducer’s position using the original TRE offset.
Contribution to Literature:
The study contributes to the current literature by providing a method to better estimate acoustic exposure during tFUS and by emphasizing the importance of image feedback for increased dosimetry accuracy. The results show that the simulated focus closely matches the predicted focus, with Euclidean distance errors of 0.5±0.1 mm for the phantom and 1.2±0.4 mm for the skull cap. The research also suggests that magnetic resonance-acoustic radiation force imaging can be used to refine treatment planning.