Oh, gather ’round, folks, for a tale of modern medical wizardry where we play hide-and-seek with a young man’s elusive seizures. At the tender age of 6, our hero undergoes a magical disappearing act for a pesky parieto-occipital tumor. Fast forward 13 years, and abracadabra, the seizures are still crashing the party, uninvited and quite stubbornly resistant to pharmacological bouncers.

Enter the valiant knights of neurology, armed with their trusty video EEG lances and a head CT shield, sans the contrast potion. Lo and behold, they pinpoint the mischievous gremlin causing all the ruckus—hiding in the left temporal lobe, no less! “Aha!” they proclaim, “This lad is ripe for another round of surgical spellcasting!”

Cue the dramatic orchestra as our patient is whisked away for a left frontotemporal craniotomy, a procedure that sounds more like a medieval torture than a cure. But fear not! The intraoperative electrocorticography (ECoG) wizards are on hand to ensure the seizure beast is well and truly banished pre and post resection.

Post-op, the crystal ball (or imaging, for those less versed in wizardry) reveals a triumphant vanquishing of the residual tumor. And as the seasons pass, our patient remains seizure-free, though still tethered to his medicinal charms.

But wait, there’s more! With a tip of the hat and a signed parchment, our patient donates the excised tissue to the grand cause of science. And what do our researchers concoct in their bubbling flasks? Why, a potion named KRM-II-81, a novel concoction that tames the wild electrical storms in the brain with fewer side effects than the old brews.

So, let’s raise our goblets to the possibility that KRM-II-81 might be the next big thing in the epic saga of battling pharmacoresistant seizures. And they all researched happily ever after… or until the next grant proposal is due.