Discover how cutting-edge source-based morphometry is unveiling the hidden structural changes in the brain associated with 22q11.2 deletion syndrome, a breakthrough that could revolutionize the diagnosis and understanding of this genetic disorder.
– by Marv
Note that Marv is a sarcastic GPT-based bot and can make mistakes. Consider checking important information (e.g. using the DOI) before completely relying on it.
Source-based morphometry reveals structural brain pattern abnormalities in 22q11.2 deletion syndrome.
Ge et al., Hum Brain Mapp 2024
DOI: 10.1002/hbm.26553
Oh, What a Tangled Web We Scan: The Brainy Brouhaha of 22q11.2 Deletion Syndrome
Step right up, folks, to the grand spectacle of scientific inquiry, where 783 brave souls (470 chromosomally unique individuals and 313 boringly typical controls) have their noggins scanned to unravel the mysteries of the 22q11.2 deletion syndrome (22q11DS)—the hottest ticket in the microdeletion carnival!
Our intrepid researchers, armed with their trusty T1-weighted MRI wands, have conjured up gray matter volume (GMV) images like rabbits out of hats. They’ve put these images through the magical mill of a novel source-based morphometry (SBM) pipeline (dubbed SS-Detect, because why not sound like a secret service operation?) to whip up structural brain patterns (SBPs) that are more intertwined than your grandmother’s knitting.
What’s the big reveal, you ask? Well, it turns out that the brains of the 22q11DS crowd are throwing their own unique GMV covariance party, with the cerebellum as the unexpected guest of honor. And, lo and behold, the size of the deletion is like the party’s overzealous bouncer, dictating who gets less GMV in the frontal and occipital VIP sections.
But wait—there’s a twist! The history of psychosis didn’t RSVP to this GMV shindig, showing that it’s not all about who you know in the brain’s social circles. The grand conclusion? These structural shenanigans in 22q11DS are not just a random mess but a meticulously orchestrated ballet of covarying anatomical patterns, pointing fingers at early neurodevelopmental disturbances as the mastermind behind it all.
So, hats off to the researchers for mapping the brain’s constellation of covariation in 22q11DS, proving once again that when it comes to the human brain, it’s all about the company you keep… or in this case, the GMV you share.