Discover how the intricate dance between lncRNA-mir3471-limd1 regulatory network could unlock new understandings in the fight against Hypoxic-Ischemic Brain Damage (HIBD) in neonates.
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LncRNA-mir3471-limd1 regulatory network plays critical roles in HIBD.
Sun et al., Exp Brain Res 2023
DOI: 10.1007/s00221-023-06755-x
What’s New: The study identifies limd1 as a target gene of the lncRNA tcon_00044595 and implicates miR-3471 in the regulation of limd1, which may play a role in the pathogenesis of neonatal hypoxic-ischemic brain damage (HIBD).
Importance: This research provides a deeper understanding of the molecular interactions involved in HIBD, which could lead to the development of targeted therapies for this condition.
Contribution to Literature: The study expands on the current knowledge by elucidating the interaction between a specific lncRNA and microRNA with a gene associated with HIBD, a significant step in unraveling the complex gene regulation mechanisms in this disease.
Summary of Results:
– limd1 identified as a target gene for lncRNA tcon_00044595, with a 246 bp homologous sequence and 68% conservation.
– miR-3471 significantly down-regulates limd1 expression, unlike miR-883a-5p and miR-214-3p.
– Two interaction sites between miR-3471 and limd1 3’UTR discovered, with UTR-1 having a strong influence.
– miR-3471 shows a protective effect in low oxygen conditions relevant to HIBD.
This study suggests a regulatory relationship between lncRNA tcon_00044595, miR-3471, and limd1, offering new avenues for understanding and treating HIBD.